N-Heterocyclic carbene-catalyzed oxidations

N-heterocyclic carbene-catalyzed aza-Michael addition.

Aza-Michael addition of amines, including aromatic and aliphatic amines, with α, β-unsaturated ketones was realized employing N-Heterocyclic Carbene (NHC) as organocatalyst, yielding β-amino ketones with up to 98% yield.

N-heterocyclic carbene catalyzed synthesis of oxime esters.

A triazolium salt derived N-heterocyclic carbene catalyzes the redox esterification reaction between α-β-unsaturated aldehydes and oximes. The resulting saturated oxime esters were obtained in very good yields for a broad range of aliphatic, aromatic and heteroaromatic substrates.

N-heterocyclic carbene-catalyzed highly enantioselective synthesis of substituted dihydropyranopyrazolones.

Highly optically pure multisubstituted dihydropyrano[2,3-c]pyrazol-6-(1H)-ones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of α-chloroaldehydes and pyrazolone-derived oxodienes.

N-heterocyclic-carbene-catalyzed one-pot synthesis of hydroxamic esters.

Enantioselective N-heterocyclic carbene-catalyzed synthesis of indenopyrones.

The chiral N-heterocyclic carbene-catalyzed [4 + 2] cyclization of α-chloroaldehydes and arylidene indanediones was developed, giving the corresponding indenopyrones in good yields with high diastereoselectivities and enantioselectivities.